| Rickets: |
When in occurs in growing children
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| Osteomalacia: |
In adult after the growth spurts |
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| Inadequate Calcium: |
Inadequate intake of calcium.
Defect in metabolic pathway of Vit D3.
Inadequate exposure to sunlight
Intestinal malabsorption
Renal or liver disease. |
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Rickets: |
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| Clinical features: |
Failure to thrive, listlessness, muscular flaccidity, Soft skull,
Thickening of knees, ankles and wrists
Bowing / of the legs. Knock knees
Lag of growth
Scoliosis / Kyphosis of spine
Long bones deformities and fractures |
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| Osteomalacia : |
Bone pains, backaches, muscle weakness, Kyphosis, Stress fractures. |
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| Investigations |
Serum Calcium & Phosphorus – Decreased
Alkaline PO4 – Decreased
Urine Calcium – Decreased
Vitamin D3 – Decreased
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| Treatment: |
Varies on the cause |
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- Vit D3 Deficiency – Given Vit D3 + Ca++
- Vit D3 Deficiency to intestinal malabsorption – large doses of Vit D ~ 50,000 IV/day
- Renal Rickets – 1,25 Dihydroxycholicalcifenec (calcitriol)
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